Endocrine Abstracts

Objectives: To define clinical and metabolic factors associated with severe hypoglycaemia (SH) in affected individuals with Type 1 diabetes (T1DM).Methods: Individuals with T1DM and SH (defined as hypoglycaemia requiring third party intervention within the preceding 12 months) were characterised to include screening for other underlying autoimmune disease (coeliac serology, short synacthen and thyroid function tests); a questionnaire to evaluate underlyi...

Objective: To compare clinical characteristics in individuals with established Type 1 diabetes mellitus with and without altered hypoglycaemia unawareness (AHA) / severe hypoglycaemia (SH).Methods: Individuals with AHA and/or SH and controls matched for age, sex and duration of diabetes but with no history of AHA or SH were identified from databases of those attending the Newcastle Diabetes centre with Type 1 diabetes. Characteristics were confirmed from...

Introduction: The incidence of Type 1 diabetes (T1D) is rising. The effect of increasing BMI in children has been proposed. A relationship between age of diagnosis of T1D and BMI SDS has been reported by some but not confirmed in all studies. We propose age of diagnosis and autoantibody status may be influenced by BMI and inherited factors relating to BMI and insulin resistance.Methods: BMI SDS was calculated in 230 children with newly diagnosed T1D, 4&#...